Hole—a dark, decrepit, and disorderly district where the strong prey on the weak and death is an ordinary occurrence—is all but befitting of the name given to it. A realm separated from law and ethics, it is a testing ground to the magic users who dominate it. As a race occupying the highest rungs of their society, the magic users think of the denizens of Hole as no more than insects. Murdered, mutilated, and made experiments without a second thought, the powerless Hole dwellers litter the halls of Hole's hospital on a daily basis. Possessing free access to and from the cesspool, and with little challenge to their authority, the magic users appear indomitable to most—aside for a few. Kaiman, more reptile than man, is one such individual. He hunts them on a heedless quest for answers with only a trusted pair of bayonets and his immunity to magic. Cursed by his appearance and tormented by nightmares, magic users are his only clue to restoring his life to normal. With his biggest obstacle being his stomach, his female companion Nikaidou, who runs the restaurant Hungry Bug, is his greatest ally. Set in a gritty world of hellish design, Dorohedoro manages a healthy blend of comedy and lightheartedness with death and carnage. Taking plenty of twists and turns while following the lives of Hole's residents, it weaves a unique world of unearthly origin and dreary appearance not for the squeamish or easily disturbed.

OVA included with the special edition of volume two of the Blu-ray release.

OVA included with the special edition of volume two of the Blu-ray release.

A samurai lord has bartered away his newborn son's organs to forty-eight demons in exchange for dominance on the battlefield. Yet, the abandoned infant survives thanks to a medicine man who equips him with primitive prosthetics—lethal ones with which the wronged son will use to hunt down the multitude of demons to reclaim his body one piece at a time, before confronting his father. On his journeys the young hero encounters an orphan who claims to be the greatest thief in Japan.

The greedy samurai lord Daigo Kagemitsu's land is dying, and he would do anything for power, even renounce Buddha and make a pact with demons. His prayers are answered by 12 demons who grant him the power he desires by aiding his prefecture's growth, but at a price. When Kagemitsu's first son is born, the boy has no limbs, no nose, no eyes, no ears, nor even skin—yet still, he lives. This child is disposed of in a river and forgotten. But as luck would have it, he is saved by a medicine man who provides him with prosthetics and weapons, allowing for him to survive and fend for himself. The boy lives and grows, and although he cannot see, hear, or feel anything, he must defeat the demons that took him as sacrifice. With the death of each one, he regains a part of himself that is rightfully his. For many years he wanders alone, until one day an orphan boy, Dororo, befriends him. The unlikely pair of castaways now fight for their survival and humanity in an unforgiving, demon-infested world.

Hyakkimaru is a young man who lacks 48 body parts because they were taken from him by demons before birth, as payment by his father, Kagemitsu Daigo, to obtain his wish to take over the country. When the baby boy was born he was missing 48 parts of his body, and thus was abandoned—thrown into a river. Hyakkimaru has grown up and now has obtained fake body parts so he can eliminate the 48 demons that were made from his body, and to retrieve his missing parts. Along for the adventure is the boy thief, Dororo, with whom he becomes friends.

Monsters are coming to the human world from the Hell in order to get human spirits. As people's minds are getting dirty, being attracted by the dirty spirits, the monsters break the rule to go to the human world. Tsutomu, a boy who goes to Yokai Elementary School, is suddenly assaulted by monsters. Those who save him from the monsters are Enma-kun, the son of Enma, Yukiko, a snow woman, and Kapaeru. They are members of Monster Patrol that are sent to the human world to arrest monsters.

The story is set in Tokyo in the 1970s. Evil spirits are threatening the human world and the only ones who can stop them is a group known as the "Spirit Patrol", a group sent from the underworld that consists of the hot-headed Enma, the stuck-up Yukiko, the half-water sprite Kapael and Chapeau-jii - the old man spirit in the form of a hat, who guides the group.

High school boy Tsubasa moves to Kitami City up in Hokkaido where he meets a "gal" at a bus stop. The sight of her standing alone against the white snowscape, bare-legged despite the freezing cold, captures his heart.

High school boy Tsubasa moves to Kitami City up in Hokkaido where he meets a "gal" at a bus stop. The sight of her standing alone against the white snowscape, bare-legged despite the freezing cold, captures his heart.

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